Bezopasno li dlitelnoye prinyatiye gialuronovoy kisloty?
Dlitelnoye prinyatiye gialuronovoy kisloty stalo populyarnoy temoy, kak tolko peroralnyye formy etogo glikozaminoglikana poluchili shirokoe priznaniye. Estestvenno prisutstvuyushchaya v kozhe, sustavakh i soedinytelnoy tkani, gialuronovaya kislota privlekayet i uderzhivayet vodu, sposobstvuya smazyvaniyu tkaney i uvlazhneniy kozhi. Pri rastyushchey dokazatelnoy baze klinicheskikh issledovaniy, podtverzhdayushchikh peroralnoye dobavleniye, vopros o dlitelnom primenenii — bezopasen li ono, razvivayetsya li tolerantnost i chto nablyudat — zasluzhivayet chetkoго otveta.
Chto pokazyvayut dolgovremennyye issledovaniya
Peroralnnaya gialuronovaya kislota otsenivalas preimushchestvenno po dvum iskhods: komfort sustavov i uvlazhneniye kozhi. Klinicheskiye ispytaniya, kak pravilo, ispolzovaly periody priema dobavok ot odnogo do trekh mesyatsev, no nekotoryye issledovaniya rasshiryayutsya do shesti mesyatsev bez vyyavleniya problem s bezopasnostyu.
Randomizirovannoye, platsebo-kontroliruemoye ispytaniye u lyudey s osteoartrozom kolena pokazalo, chto peroralnoye dobavleniye gialuronovoy kisloty v techenie shesti mesyatsev bylo svyazano s uluchsheniyem pokazateley boli i fizicheskoy funktsii bez klinicheski znachimykh neblagopriyatnykh sobytiy (Kalman et al., 2008). Otdelnoye randomizirovannoye ispytaniye u zdorovykh zhenshchin izuchilo peroralnoye dobavleniye v techenie vosmi nedel i obnaruzhilo uluchsheniya uvlazhnennosti i elastichnosti kozhi (Oe et al., 2017). Ni odno ispytaniye ne vyyavilo signalov bezopasnosti pri izuchennykh dozakh.
Takiye produkty, kak NOW Hyaluronic Acid 50mg + MSM 60caps i OstroVit Hyaluronic acid 90tabs — dostupnyye v kategorii gialuronovoy kisloty na maxfit.ee — dostavlyayut dozy v diapazone, issledovannom v etikh ispytaniyakh.
Bezopasnye verkhnie predely vremeni
Gialuronovaya kislota ne imeet formalno ustanovlennogo dopustimogo verkhnego urovnya potrebleniya tak, kak vitaminы i mineraly. Porog toksichnosti dlya peroralnogo dobavleniya u zdorovykh vzroslykh ne opredelyon. Gialuronovaya kislota yavlyayetsya estestvenno vstrechayushcheysya v organizme molekuloy, i peroralnoye dobavleniye — dazhe pri dozakh vyshe tipichnykh kolichestvakh dobavok — ne bylo svyazano s kumulyativnoy toksichnostyu v imeyushchikhsya dokazatelstvakh.
Prakticheskoye soobrazheniyet — eto ne toksichnost, a effekt: chrezmerno vysokiye dozy ne obyzatelno dayut proportsionalno bolshey polzy. V issledovaniyakh sustavov i kozhi obychno ispolzuyutsya skromnyye ezhednevnyye kolichestva, i bolshe ne vsegda luchshe v etom kontekste.
Nuzhno li delayt kurs (tsiklirovanie)?
Dlya tsiklirovaniya primeneniya dobavok gialuronovoy kisloty net ustanovlennoy dokazatel'noy osnovy. Gialuronovaya kislota — eto ne farmakologicheskiy agent, indutsiruyushchiy tolerantnost ili daunregulyatsiyu retseptorov. Yeyo effekty v znachitelnoy stepeni strukturnyye — ona sposobstvuyet vodosvy azyvayushchey sposobnosti vnekletochnogo matriksa — i eti effekty ozhidayutsya, poka prodolzhaetsya priyom dobavok.
Nekotoryye lyudi predpochitayut delatpereryv v priyme dobavok v bolee tyopyye mesyatsy, kogda simptomy sustavov obychno menee vyrazheny, a zatem vozobnovlyayut ikh osenyyu i zimoy. Eto lichnoye predpochteniye, a ne meditsinskie protsikovanny protokol.
Monitoring
Dlya zdorovykh vzroslykh ne trebuetsya spetsialnogo monitoringa pri priyme peroralnykh dobavok gialuronovoy kisloty. Neblagopriyatnyye sobytiya v klinicheskikh ispytaniyakh byli redkimi i nezначitelnymi, ogranichivaysya, kak pravilo, prekhodyashchimi zheludochno-kishechnymi zhalobami (toshnota, chuvstvo tяzhesti) u nebolshoy chasti uchastnikov.
Odin zasluzhivayushchiy vnimaniya moment: gialuronovaya kislota igrayet biologicheskuyu rol v migratsii rakovykh kletok i remodelirovanii tkaney. Khotya chelovecheskiye dokazatelstva ne svyazyvayut peroralnoye dobavleniye s riskom razvitiya raka, nekotoryye onkologi rekomenduyut patsiyentam s aktivnym rakom ili nedavney onkologicheskoy istoriyey obsuzhdeat lyubye dobavki gialuronovoy kisloty so svoey meditsinskoy komandoy. Eto razumnaya predostoroshchnost, a ne ustanovlennyy risk.
Chestnoye zaklyucheniye
Imeyushchiyesya klinicheskiye dokazatelstva podtverzhdayut bezopasnost dlitelnogo peroralnogo primeneniya gialuronovoy kisloty u zdorovykh vzroslykh. Ispytaniya prodolzhitelnostyu do shesti mesyatsev pri tipichnykh dobavochnykh dozakh ne vyyavili znachimykh neblagopriyatnykh effektov i porog toksichnosti ne byl ustanovlen. Dlya dvukh osnovnykh primeneniy — komforta sustavov i uvlazhneniya kozhi — effekty, po-vidimomu, sohranayutsya pri nepreryvnom ispolzovanii i mogut umenshitsya posle otkaza.
Gialuronovaya kislota khorosho podkhodit kak dolgorochnaya ezhednevnaya dobavka, a ne ostraya ili tsiklicheskaya. Esli у vas yest soprovoditelnye sostoyanya zdorovya, osobenno svyazannyye s soyedinytelnoy tkanyu, vospaleniyem ili onkologicheskoy istoriyey, razumno kratko omyslit eto s vashim vrachom pered nachalом primeneniya.
Kategoriya gialuronovoy kisloty na MaxFit predlagayet neskolko khorosho izuchennykh formatov dlya peroralnykh dobavok.
CHAVO
Kak dolgo zanimayet poyavleniye rezultatov ot peroralnoy gialuronovoy kisloty?
Bolshinstvo klinicheskikh ispytaniy, nablyudayushchikh uluchsheniya uvlazhnennosti kozhi ili komforta sustavov, soobshchayut ob izmeneniyakh cherez chetyre-vosem nedel. Individualnaya reaktsiya razlichaetsya, i dlya polucheniya i podderzhki effektov neobkhodimo postoyannoye ezhednevnoye ispolzovaniye.
Mogu li ya kombinirovat gialuronovuyu kislotu s kollagenom i vitaminom S?
Da, i eto razumnoye sochetaniye. Kollagen obespechivayet strukturnyye aminokisloty dlya khryashcha i kozhi; vitamin S neobkhodim dlya sinteza kollagena; gialuronovaya kislota sposobstvuyet zaderzhaniyu vody i smazyvaniyu sustavov. Vse tri deystvuyut cherez dopolnitelnyye mekhanizmy.
Bezopasneye li inektsiруemaya gialuronovaya kislota, chem peroralnaya dobavka?
In ektsionaya gialuronovaya kislota (primenyayemaya v dermatologii i ortopedii) i peroralnyye dobavki sil'no otlichayutsya s tochki zreniya mekhanizma i profilya riska. In ektsii — eto meditsinskiye protsedury so svoyey diskussiyey o plyusakh i minusakh. Peroralnyye dobavki v dozakh pishchevogo kachestva imeyut otlichnyy i znachitelno bolee dobrokachestvennyy profil bezopasnosti.
Ssylki
Kalman, D. S., Heimer, M., Valdeon, A., Schwartz, H., & Sheldon, E. (2008). Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. Nutrition Journal, 7, 3.
Oe, M., Sakai, S., Yoshida, H., Okado, N., Kaneda, H., Masuda, Y., & Urushibata, O. (2017). Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Clinical, Cosmetic and Investigational Dermatology, 10, 267-273.
Ueno, M., Murota, H., Takagishi, K., Igawa, K., & Murota, H. (2013). Ingested hyaluronan supports the synthesis of skin and joint hyaluronan. Food & Nutrition Research, 57, 20630.
