Resveratrol activates sirtuins and AMPK — cellular longevity pathways that regulate DNA repair, inflammation, and energy metabolism. Animal studies show lifespan extension, but human studies are still in early stages. What is clear is that resveratrol protects cells from oxidative stress and supports cardiovascular health — both important factors in healthy aging.

Studies use 150-500 mg of trans-resveratrol per day. For cardiovascular support, 150-250 mg is often sufficient. For antioxidant and anti-aging protection, 250-500 mg per day is recommended. Trans-resveratrol is the more biologically active form than cis-resveratrol — check the product label. Take with fatty food for better absorption.

Red wine contains resveratrol, but in very small amounts — about 1-2 mg per glass. To consume the dose needed for health benefits (150-500 mg), you would need to drink hundreds of glasses of wine per day, which would be harmful. Supplements provide a therapeutic dose without the negative effects of alcohol. So wine does not replace a supplement.

Resveratrol is typically well tolerated at doses up to 500 mg per day. Some people may experience mild gastrointestinal symptoms such as nausea or diarrhea. At high doses (over 1,000 mg), resveratrol may have blood-thinning effects — caution is needed for those taking anticoagulant medications. Use during pregnancy and breastfeeding has not been sufficiently studied.